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LRE1

SIGMA/SML1857 - ≥98% (HPLC)

Synonym: 6-Chloro-N4-cyclopropyl-N4-(2-thienylmethyl)-2,4-pyrimidinediamine; RU-0204277

CAS Number: 1252362-53-0
Empirical Formula (Hill Notation): C12H13ClN4S
Molecular Weight: 280.78
MDL Number: MFCD23148480
Linear Formula: C12H13ClN4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1857-5MG 5 mg
 $116.00
1/EA		 Add To Favorites
45-SML1857-25MG 25 mg
 $467.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI key PDWZXKSZLRVSEH-UHFFFAOYSA-N
Quality Level 100 
SMILES string ClC1=CC(N(C2CC2)CC3=CC=CS3)=NC(N)=N1
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: LRE1 is a selective allosteric inhibitor of soluble adenylyl cyclase (sAC), a ubiquitously expressed, essential component of cAMP-signaling. In contrast to G-protein-regulated transmembrane adenylyl cyclase, soluble adenylyl cyclase is directly activated by calcium and carbonate, and is dispersed throughout the cell cytoplasm. LRE1 was found to bind to the bicarbonate activator binding site. It inhibited cAMP accumulation in 4-4 cells with an IC50 of 11 μM, similar to that of KH7 and without its cellular toxicity.
Biochem/physiol Actions: Selective allosteric inhibitor of soluble adenylyl cyclase (sAC)
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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