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AZD2461

SIGMA/SML1858 - ≥98% (HPLC)

Synonym: 4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one; 4-[[4-Fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone; AZD 2461; AZD-2461

CAS Number: 1174043-16-3
Empirical Formula (Hill Notation): C22H22FN3O3
Molecular Weight: 395.43
MDL Number: MFCD24386811
Linear Formula: C22H22FN3O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1858-5MG 5 mg
 $108.00
1/EA		 Add To Favorites
45-SML1858-25MG 25 mg
 $436.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C22H22FN3O3/c1-29-15-8-10-26(11-9-15)22(28)18-12-14(6-7-19(18)23)13-20-16-4-2-3-5-17(16)21(27)25-24-20/h2-7,12,15H,8-11,13H2,1H3,(H,25,27)
InChI key HYNBNUYQTQIHJK-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C1NN=C(CC2=CC=C(F)C(C(N3CCC(OC)CC3)=O)=C2)C4=CC=CC=C41
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: AZD2461, an olaparib analog, is an orally available, potent and selective PARP1 and PARP2 inhibitor that is a poor substrate for drug transporters. AZD2461 exhibits a high efficacy in olaparib-resistant tumors that overexpress P-glycoprotein.
Biochem/physiol Actions: Orally available, potent and selective PARP1 and PARP2 inhibitor that is a poor substrate for drug transporters
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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