TP-472
SIGMA/SML1862 - ≥98% (HPLC)
Synonym: 3-
Empirical Formula (Hill Notation): C20H19N3O2
Molecular Weight: 333.38
Linear Formula: C20H19N3O2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| Quality Level | 100  |
| SMILES string | O=C(C)C1=CC(C2=C(C)C=CC(C |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | TP-472 is a selective probe for bromodomain-containing proteins BRD9 and BRD7. This BRD9/7 probe was developed out of a collaborative effort by Takeda and the SGC, and is of a different chemotype from BRD9/7 probes previously available. TP-472 has a KD value of 33nM for BRD9 and 340nM for BRD7 by ITC. It is >30 fold selective for BRD9 over all other bromodomain family members except BRD7. It is suitable for in vivo applications. For full characterization details, please visit the TP-472 probe summary  on the Structural Genomics Consortium (SGC) website.TP-472N is used as a negative control and is available from Sigma. To learn more about and purchase TP-472N, click here .To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc |
| Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | TP-472 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |