NSC57969
SIGMA/SML1863 - ≥98% (HPLC)
Synonym: 7-
CAS Number: 6632-09-3
Empirical Formula (Hill Notation): C15H18N2O
Molecular Weight: 242.32
MDL Number: MFCD00469245
Linear Formula: C15H18N2O
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C15H18N2O/c18-15-13(11 |
InChI key | WXMFPLZGDXLEMN-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | OC1=C(N=CC=C2)C2=CC=C1CN3 |
solubility | DMSO: 5 mg/mL, clear (warmed) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | NSC57969 is a MDR-selective compound that exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines. NSC57969 shows profound toxicity against doxorubicin resistant Brca1-/-;p53-/- spontaneous mouse mammary carcinoma cells. NSC57969 eradicates P-glycoprotein expression in doxorubicin resistant brca1-/-;p53-/- spontaneous mouse mammary carcinoma, and MES-SA/Dx5 cells. However treatment of normal cells (hCMEC/D3 cells) with NSC57969 does not induce loss of Pgp. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |