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NSC57969

SIGMA/SML1863 - ≥98% (HPLC)

Synonym: 7-(1-Piperidinylmethyl)-8-quinolinol; 7-(Piperidinomethyl)-8-quinolinol; 8-Hydroxy-7-(piperidinomethyl)quinoline

CAS Number: 6632-09-3
Empirical Formula (Hill Notation): C15H18N2O
Molecular Weight: 242.32
MDL Number: MFCD00469245
Linear Formula: C15H18N2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1863-5MG 5 mg
 $78.40
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C15H18N2O/c18-15-13(11-17-9-2-1-3-10-17)7-6-12-5-4-8-16-14(12)15/h4-8,18H,1-3,9-11H2
InChI key WXMFPLZGDXLEMN-UHFFFAOYSA-N
Quality Level 100 
SMILES string OC1=C(N=CC=C2)C2=CC=C1CN3CCCCC3
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: MDR-selective compound that exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines
Biochem/physiol Actions: NSC57969 is a MDR-selective compound that exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines. NSC57969 shows profound toxicity against doxorubicin resistant Brca1-/-;p53-/- spontaneous mouse mammary carcinoma cells. NSC57969 eradicates P-glycoprotein expression in doxorubicin resistant brca1-/-;p53-/- spontaneous mouse mammary carcinoma, and MES-SA/Dx5 cells. However treatment of normal cells (hCMEC/D3 cells) with NSC57969 does not induce loss of Pgp.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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