NVS-PAK1-1
SIGMA/SML1867 - ≥98% (HPLC)
Synonym: (S)
CAS Number: 1783816-74-9
Empirical Formula (Hill Notation): C23H25ClF3N5O
Molecular Weight: 479.93
Linear Formula: C23H25ClF3N5O
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | FC(F)CN1C2=C(C=C(Cl)C=C2) |
solubility | DMSO: 30 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. NVS-PAK1-1 showed good selectivity against 442 other kinases including PAK2. NVS-PAK1-1 has generally good physicochemical properties, but was metabolized by rat liver microsomes, so may not be useful for in vivo work. For full characterization details, please visit the NVS-PAK1-1 probe summary ![]() ![]() To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc ![]() |
Features and Benefits: | NVS-PAK1-1 is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC ![]() |
Features and Benefits: | This compound is a featured product for Kinase Phosphatase Biology research. Click here ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |