Brusatol

SIGMA/SML1868 - ≥95% (HPLC)

Synonym: (+)-Brusatol; (11β,12α,15β)-13,20-Epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-picras-3-en-21-oic acid methyl ester; Brutasol; NSC 172924; Yatansin

CAS Number: 14907-98-3
Empirical Formula (Hill Notation): C₂₆H₃₂O₁₁
Molecular Weight: 520.53
MDL Number: MFCD23726642
Linear Formula: C₂₆H₃₂O₁₁
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1868-5MG	5 mg	$121.00 1/EA	Add To Favorites
45-SML1868-25MG	25 mg	$491.00 1/EA	Add To Favorites

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This image depicts SML1868-25MG.

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
biological source	(Brucia javanica)
color	white to beige
form	powder
InChI	1S/C26H32O11/c1-10(2)6-15(28)37-18-20-25-9-35-26(20,23(33)34-5)21(31)17(30)19(25)24(4)8-13(27)16(29)11(3)12(24)7-14(25)36-22(18)32/h6,12,14,17-21,29-31H,7-9H2,1-5H3/t12-,14+,17+,18+,19+,20+,21-,24-,25+,26-/m0/s1
InChI key	ZZZYHIMVKOHVIH-VILODJCFSA-N
optical activity	[α]/D +35 to +44°, c = 0.5 in acetone
Quality Level	100
SMILES string	CC1=C(O)C(C[C@@]2(C)[C@@]1([H])C[C@]3([H])[C@]45[C@]2([H])[C@@H](O)[C@H](O)[C@](OC5)(C(OC)=O)[C@]4([H])[C@@H](OC(C=C(C)C)=O)C(O3)=O)=O
solubility	DMSO: 5 mg/mL, clear (warmed)
storage condition	desiccated
storage temp.	−20°C

Application:	Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury.
Biochem/physiol Actions:	Brusatol (Brutasol) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC₅₀<1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. <50 nM in A549 cells), including NRF2.
Biochem/physiol Actions:	Brusatol (Brutasol) is a plant-derived natural quassinoid that exhibits broad cytotoxicity.
Biochem/physiol Actions:	Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation. Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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