SPL-334

SIGMA/SML1880 - ≥98% (HPLC)

Synonym: 4-{[2-[(2-Cyanobenzyl)thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl}benzoic acid

CAS Number: 688347-51-5
Empirical Formula (Hill Notation): C₂₂H₁₅N₃O₃S₂
Molecular Weight: 433.50
MDL Number: MFCD05032783
Linear Formula: C₂₂H₁₅N₃O₃S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1880-5MG	5 mg	$98.40 1/EA	Add To Favorites
45-SML1880-25MG	25 mg	$397.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI key	UWWSCLNCHCROLL-UHFFFAOYSA-N
Quality Level	100
SMILES string	OC(C1=CC=C(CN2C(SCC3=CC=CC=C3C#N)=NC(C=CS4)=C4C2=O)C=C1)=O
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	SPL-334 is an inhibitor of S-Nitrosoglutathione reductase (GSNOR), the enzyme responsible for regulating cellular concentrations of S-Nitrosoglutathione (GSNO), which plays a critical role in nitric oxide signaling in the respiratory tract. In a mouse model of allergic airway inflammation, SPL-334 reduced airway hyperreactivity, and in a bleomycin injury model of interstitial lung disease, SPL-334 reduced lung inflammation and fibrosis. Studies for treatment of asthma, idiopathic pulmonary fibrosis (IPF), and inflammation are ongoing.
Biochem/physiol Actions:	SPL-334 is an inhibitor of S-Nitrosoglutathione reductase (GSNOR).
Packaging:	5, 25 mg in glass bottle

Hazard statements	H413
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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