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RS 67333 hydrochloride

SIGMA/SML1882 - ≥98% (HPLC)

Synonym: 1-(4-Amino-5-chloro-2-methoxy-phenyl)-3-[1(n-butyl)-4-piperidinyl]-1-propanone hydrochloride; 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-1-propanone hydrochloride; RS-67,333 hydrochloride; RS-67333 hydrochloride; RS67333 hydrochloride

CAS Number: 168986-60-5
Empirical Formula (Hill Notation): C19H29ClN2O2 ·HCl
Molecular Weight: 389.36
MDL Number: MFCD00938576
Linear Formula: C19H29ClN2O2 ·HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1882-5MG 5 mg
 $116.00
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45-SML1882-25MG 25 mg
 $467.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1882-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C19H29ClN2O2.ClH/c1-3-4-9-22-10-7-14(8-11-22)5-6-18(23)15-12-16(20)17(21)13-19(15)24-2;/h12-14H,3-11,21H2,1-2H3;1H
InChI key XVBGLZNYWUUAFF-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(C1=CC(Cl)=C(N)C=C1OC)CCC2CCN(CCCC)CC2.[H]Cl
solubility H2O: 1 mg/mL, clear (warmed)
storage condition desiccated
storage temp. room temp
Biochem/physiol Actions: A selective and potent 5-HT4 partial agonist with in vitro and in vivo efficacy.
Biochem/physiol Actions: RS 67333 is a selective, high affinity (pKi = 8.7 for the 5-HT4 binding site in guinea-pig striatum) partial agonist toward 5-HT4 receptor that relaxes carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pEC50/%reversal = 8.7/50 with RS 67333 vs. 8.2/100 with 5-HT) and induces tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (ED50 via i.p. in μg/kg over max heart rate increase in beats/min = 4.9/35 with RS 67333 vs. 3.2/95 with 5-HT). RS 67333 is also reported to show high affinity for sigma receptors (pKi = 8.9/σ1 and 8.0/σ2), while exhibiting much reduced affinity toward a panel of other receptors, including 5-HT1A, 5-HT2A, 5-HT2C, 5-HT3 (pKi <6.4), muscarinic receptors (pKi = 5.2/M1 & 5.3/M2), and adrenoceptors (pKi <6.7 for α1A, α1B, α2A, α2B, β1, β2).
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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