Mitotane

SIGMA/SML1885 - ≥98% (HPLC)

Synonym: 1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane; 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]-benzene; 2,4′-DDD; o,p′-DDD

CAS Number: 53-19-0
Empirical Formula (Hill Notation): C₁₄H₁₀Cl₄
Molecular Weight: 320.04
EC Number: 200-166-6
MDL Number: MFCD00000850
Linear Formula: C₁₄H₁₀Cl₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1885-100MG	100 mg	$57.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
InChI key	JWBOIMRXGHLCPP-UHFFFAOYSA-N
Quality Level	100
SMILES string	ClC1=C(C(C(Cl)Cl)C2=CC=C(Cl)C=C2)C=CC=C1
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	Mitotane is a selective inhibitor of sterol-Oacyl-transferase 1 (SOAT1), also known as ACAT1, (acyl-coenzyme A cholesterol acyltransferase).
Biochem/physiol Actions:	Mitotane is a selective inhibitor of sterol-Oacyl-transferase 1 (SOAT1), also known as ACAT1, (acyl-coenzyme A cholesterol acyltransferase). Mitotane inhibition of SOAT1 in adrenocortical carcinoma cells decreased the formation of cholesteryl esters, which increased free cholesterol levels and caused endoplasmic reticulum (ER) stress, the unfolded protein response, and eventually apoptosis.
Packaging:	100 mg in glass bottle

Symbol	GHS08
Signal word	Warning
Hazard statements	H351
Precautionary statements	P280
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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