PK11007

SIGMA/SML1891 - ≥98% (HPLC)

Synonym: 5-Chloro-2-(methylsulfonyl)-4-pyrimidinecarboxylic acid

CAS Number: 38275-34-2
Empirical Formula (Hill Notation): C₆H₅ClN₂O₄S
Molecular Weight: 236.63
MDL Number: MFCD00507244
Linear Formula: C₆H₅ClN₂O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1891-5MG	5 mg	$98.40 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C6H5ClN2O4S/c1-14(12,13)6-8-2-3(7)4(9-6)5(10)11/h2H,1H3,(H,10,11)
InChI key	WZUPWJVRWIVWEF-UHFFFAOYSA-N
Quality Level	100
SMILES string	[S](=O)(=O)(C)c1nc(c(cn1)Cl)C(=O)O
solubility	H₂O: 10 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:

PK11007 is a thiol-reactive anticancer agent that stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding.

Biochem/physiol Actions:

PK11007 is a thiol-reactive anticancer agent that stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding. Additionally independently from p53, PK11007 impairs reactive oxygen species (ROS) detoxification in a number of mutant p53 cancer cells. PK11007 exhibits anticancer activity in number of cancer cell lines while shoving low cytotoxicity toward normal cells.

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319
Precautionary statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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