VH298
SIGMA/SML1896 - ≥98% (HPLC)
Synonym: (2S,4R)
CAS Number: 2097381-85-4
Empirical Formula (Hill Notation): C27H33N5O4S
Molecular Weight: 523.65
Linear Formula: C27H33N5O4S
Product Type: Chemical
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This image depicts SML1896-5MG.
This image depicts SML1896-5MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI key | NDVQUNZCNAMROD-RZUBCFFCSA |
| ligand | VH298 |
| Quality Level | 100  |
| reaction suitability | reagent type: ligand |
| SMILES string | [s]1cnc(c1c2ccc(cc2)CNC(= |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | VH298 is a cell-permeable small molecule that disrupts the interaction of VHL with Hypoxia-inducible factor HIF-α, stabilizing HIF-α and inducing a hypoxic response. |
| Biochem/physiol Actions: | VH298 is a cell-permeable small molecule that disrupts the interaction of VHL with Hypoxia-inducible factor HIF-α, stabilizing HIF-α and inducing a hypoxic response. Hypoxia-inducible factors (HIFs) are oxygen-sensitive transcription factors that regulate hypoxic signalling. They are regulated by oxygen-dependent prolyl hydroxylase domain (PHD) enzymes and polyubiquitination by the von Hippel–Lindau (VHL) Cullin RING E3 ubiquitin ligase complex. Unlike many PHD inhibitors, which have off-target effects, VH298 acts downstream of the PHD enzymes, inhibiting the VHL:HIF-α interaction. VH298 had a Kd of 90 nM. VH298 was shown to induce HIF transcriptional activity, to increase accumulation of HIF-α in HeLa cells and to stimulate erythropoietin production in RCC4 cells. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |