NSC73306

SIGMA/SML1897 - ≥98% (HPLC)

Synonym: 2-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)-N-(4-methoxyphenyl)hydrazinecarbothioamide; NSC 671054; NSC 73304

CAS Number: 79560-74-0
Empirical Formula (Hill Notation): C₁₆H₁₄N₄O₂S
Molecular Weight: 326.37
Linear Formula: C₁₆H₁₄N₄O₂S
Product Type: Chemical

assay	≥98% (HPLC)
color	, yellow to light brown
form	powder
InChI	1S/C16H12Cl2N4O2S/c1-24-10-4-2-9(3-5-10)19-16(25)22-21-14-11-6-8(17)7-12(18)13(11)20-15(14)23/h2-7H,1H3,(H2,19,22,25)(H,20,21,23)
InChI key	HPXWWBMVIMFLLU-UHFFFAOYSA-N
Quality Level	100
SMILES string	S=C(NN=C2c3c(c(cc(c3)Cl)Cl)NC2=O)Nc1ccc(cc1)OC
solubility	DMSO: 10 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	NSC73306, a thiosemicarbazone, is a cell penetrant, cytotoxic agent that exhibits greater toxicity against cells expressing functional P-gp (P-glycoprotein) than against other cells.
Biochem/physiol Actions:	NSC73306, a thiosemicarbazone, is a cell penetrant, cytotoxic agent that exhibits greater toxicity against cells expressing functional P-gp (P-glycoprotein) than against other cells. Irrespective of variations in cell line background, NSC73306 consistently demonstrated a Pgp-potentiated MDR-selective toxicity. It appears that NSC73306 is transported into the cell by copper transporter 1 (CTR1, SLC31A1). It is not P-gp inhibitor.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable