SR144528

SIGMA/SML1899 - ≥98% (HPLC)

Synonym: 5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide; SR-144528

CAS Number: 192703-06-3
Empirical Formula (Hill Notation): C₂₉H₃₄ClN₃O
Molecular Weight: 476.05
MDL Number: MFCD05662316
Linear Formula: C₂₉H₃₄ClN₃O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1899-5MG	5 mg	$162.00 1/EA	Add To Favorites
45-SML1899-25MG	25 mg	$640.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22-,27-,29+/m1/s1
InChI key	SUGVYNSRNKFXQM-XRHWURSXSA-N
Quality Level	100
SMILES string	C[C@]12[C@H](NC(C3=NN(CC4=CC=C(C)C=C4)C(C5=CC=C(Cl)C(C)=C5)=C3)=O)C(C)(C)[C@@H](C2)CC1
solubility	DMSO: 10 mg/mL, clear
storage temp.	−20°C

Application:	SR144528 has been used as a cannabinoid CB2 receptor antagonist: • to study its blocking effect on the anti-dyskinetic functionality of HU-308 • to study its effects on spontaneous excitatory postsynaptic currents (sEPSCs) from the globus pallidus neurons • to analyze its effect on the gastric emptying in rats
Biochem/physiol Actions:	SR144528 is a potent and highly selective cannabinoid CB2 receptor inverse agonist.
Biochem/physiol Actions:	SR144528 is a potent and highly selective cannabinoid CB2 receptor inverse agonist. SR144528 exhibited a Ki of 0.6 nM at CB2 compared to 400 nM at the related CB1 receptor.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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