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Sobetirome

SIGMA/SML1900 - ≥98% (HPLC)

Synonym: 2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid; 3,5-Dimethyl-4-(4′-hydroxy-3′-isopropylbenzyl)phenoxyacetic acid; GC 1; GC-1

CAS Number: 211110-63-3
Empirical Formula (Hill Notation): C20H24O4
Molecular Weight: 328.40
Linear Formula: C20H24O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1900-5MG 5 mg
 $121.00
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45-SML1900-25MG 25 mg
 $491.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C20H24O4/c1-12(2)17-9-15(5-6-19(17)21)10-18-13(3)7-16(8-14(18)4)24-11-20(22)23/h5-9,12,21H,10-11H2,1-4H3,(H,22,23)
InChI key QNAZTOHXCZPOSA-UHFFFAOYSA-N
Quality Level 100 
SMILES string O(CC(=O)O)c1cc(c(c(c1)C)Cc2cc(c(cc2)O)C(C)C)C
solubility DMSO: 10 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: Sobetirome is also termed as 2-(4-(4-(benzyloxy)-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid/ GC-1. It has an inner-ring and negatively charged carboxylate groups at physiological pH. Sobetirome is considered as a cholesterol lowering agent in humans.
Biochem/physiol Actions: Sobetirome is an orally active and potent agonist at thyroid hormone receptor (TR) β and TRα that displays selective tissue action.
Biochem/physiol Actions: Sobetirome is an orally active and potent agonist at thyroid hormone receptor (TR) β and TRα that displays selective tissue action. Sobetirome is devoid of thyrotoxic adverse effects on the heart, bone, and skeletal muscle.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 51111800

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