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ML348

SIGMA/SML1901 - ≥98% (HPLC)

Synonym: ML 348; ML-348; N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)-1-piperazinyl]acetamide

CAS Number: 899713-86-1
Empirical Formula (Hill Notation): C18H17ClF3N3O3
Molecular Weight: 415.79
Linear Formula: C18H17ClF3N3O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1901-5MG 5 mg
 $116.00
1/EA		 Add To Favorites
45-SML1901-25MG 25 mg
 $467.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C18H17ClF3N3O3/c19-13-4-3-12(18(20,21)22)10-14(13)23-16(26)11-24-5-7-25(8-6-24)17(27)15-2-1-9-28-15/h1-4,9-10H,5-8,11H2,(H,23,26)
InChI key OXKNHBBDOIMFFQ-UHFFFAOYSA-N
Quality Level 100 
SMILES string FC(F)(F)c1cc(c(cc1)Cl)NC(=O)CN2CCN(CC2)C(=O)c3[o]ccc3
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: ML348 is a substrate-competitive, reversible and APT1-selective acyl-protein thioesterase (APT) inhibitor (IC50/Ki = 840 nM/300 nM against APT1; IC50 & Ki >10 μM against APT2). ML348 effectively inhibits cellular APT1 activity in cultures (by >95% in HEK293T & mouse T cells; 5 μM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT2.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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