IMB5046

SIGMA/SML1903 - ≥98% (HPLC)

Synonym: 2-(4-Morpholinyl)-5-nitro-benzoic acid [4-(methylthio)phenyl]methyl ester

CAS Number: 1001571-08-9
Empirical Formula (Hill Notation): C₁₉H₂₀N₂O₅S
Molecular Weight: 388.44
Linear Formula: C₁₉H₂₀N₂O₅S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1903-5MG	5 mg	$69.30 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C19H20N2O5S/c1-27-16-5-2-14(3-6-16)13-26-19(22)17-12-15(21(23)24)4-7-18(17)20-8-10-25-11-9-20/h2-7,12H,8-11,13H2,1H3
InChI key	VPXGOSNPXCNGAI-UHFFFAOYSA-N
Quality Level	100
SMILES string	O=C(C1=C(N2CCOCC2)C=CC([N+]([O-])=O)=C1)OCC3=CC=C(SC)C=C3
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	IMB5046 is a microtubule inhibitor that has antitumor activity, overcoming multidrug-resistance.
Biochem/physiol Actions:	IMB5046 is a microtubule inhibitor that has antitumor activity, overcoming multidrug-resistance. IMB5046 was cytotoxic with an IC₅₀ range of 37 to 426 nM against multiple tumor cell lines, including some that were resistant to colchicine, vincristine and paclitaxel. IMB5046 was also active against human lung tumor xenografts. IMB5046 was found to bind to tubulin at the colchicine site, but with a different binding mode. IMB5046 inhibited tubulin polymerization, and induced G2/M arrest.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352202

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