ESI-05
SIGMA/SML1907 - ≥98% (HPLC)
Synonym: 1,3,5-
CAS Number: 5184-64-5
Empirical Formula (Hill Notation): C16H18O2S
Molecular Weight: 274.38
MDL Number: MFCD00091573
Linear Formula: C16H18O2S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C16H18O2S/c1-11-5-7-15 |
| InChI key | CGPHOZWFSFNOEQ-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CC1=CC=C(S(C2=C(C)C=C(C)C |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | room temp |
| Application: | ESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury. |
| Biochem/physiol Actions: | ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. |
| Biochem/physiol Actions: | ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 μM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |