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RS 23597-190

SIGMA/SML1909 - ≥98% (HPLC)

Synonym: 3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride; RS 23597; RS-23,597-190; RS-23597; RS-23597-190; RS23597; RS23597-190

CAS Number: 149719-06-2
Empirical Formula (Hill Notation): C16H23ClN2O3 · HCl
Molecular Weight: 363.28
Linear Formula: C16H23ClN2O3 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1909-5MG 5 mg
 $98.40
1/EA		 Add To Favorites
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C16H23ClN2O3.ClH/c1-21-15-11-14(18)13(17)10-12(15)16(20)22-9-5-8-19-6-3-2-4-7-19;/h10-11H,2-9,18H2,1H3;1H
InChI key QLZLBYYNMGQIAR-UHFFFAOYSA-N
Quality Level 100 
SMILES string [Cl-].Clc1c(cc(c(c1)C(=O)OCCCN2CCCCC2)OC)N.[H+]
solubility H2O: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy.
Biochem/physiol Actions: RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy. RS 23597-190 is a 4-amino-5-chloro-2-methoxybenzoate that antagonizes 5-HT-mediated relaxation of carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pA2 = 7.5) and prevents 5-HT-induced tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (6 mg/kg RS 23597-190 and 3-10 &amp;mu;/kg 5-HT via i.v.) by targeting 5-HT4 with high affinity (pKB = 7.8) and selectivity, while exhibiting no efficacy against 5-methoxytryptamine-mediated 5-HT3 activation in guinea-pig ileum and displaying much reduced or little affinity toward 5-HT3 (pKi = 5.7/mouse NG108-15 cells and pKB &amp;lt;5/guinea-pig ileum), dopamine receptors (pKi &amp;lt;4/D1 &amp; &lt;3/D2), muscarinic receptors (pKi &lt;4.5 toward M1/2/3/4), 5-HT1A &amp; 5-HT2 (pKi <5.2).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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