ASB14780
SIGMA/SML1913 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 1069046-00-9
Empirical Formula (Hill Notation): C31H27NO3 · C4H11NO3
Molecular Weight: 582.69
Linear Formula: C31H27NO3 · C4H11NO3
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1913-5MG.
This image depicts SML1913-5MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C31H27NO3.C4H11NO3/c33 |
| InChI key | MBPXGBINIINSEU-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | O=C(O)CCC1=CC2=C(N(C3=CC= |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | ASB14780 can be a potential therapeutic for the treatment of asthma and other pulmonary diseases. In addition, its inhibitory function on group IVA phospholipase A2 (IVA-PLA2) qualifies this drug to be a potential candidate for the treatment of non-alcoholic fatty liver diseases. |
| Biochem/physiol Actions: | ASB14780 is an indole-based selective and potent cytosolic phospholipase A2α inhibitor (IC50 = 20 nM/cPLA2α and >10 μM/sPLA2α). ASB14780 inhibits cPLA2α-dependent inflammatory responses both in cultures and in animals in vivo, including LPS-induced PGE2 production (IC50 = 0.5 μM; mouse peritoneal exudate cells), A23187-induced TXB2 production (IC50 = 0.54 and 0.64 μM using guinea pig and human whole blood, respectively), TPA-induced ear edema (50 mg/kg, p.o.; mice), OVA-induced asthma (5 - 20 mg/kg/d, p.o.; guinea pig), CCl4-induced hepatic fibrosis and high-fat cholesterol diet-induced fatty liver (0.1-0.3 g/kg/d, p.o.; mouse). SB14780 bioavailability is also demonstrated in dog and monkey, albeit at a lower value (F = 34.3%/dog and 30.9%/monkey vs. 89.6%/mouse). |
| Biochem/physiol Actions: | ASB14780 is an indole-based selective and potent cytosolic phospholipase A2α inhibitor. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |