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TUG-891

SIGMA/SML1914 - ≥98% (HPLC)

Synonym: 3-(4-((4-Fluoro-4-methyl-[1,1-biphenyl]-2-yl)methoxy)phenyl)-propanoic acid; 4-[(4-Fluoro-4′-methyl[1,1′-biphenyl]-2-yl)methoxy]-benzenepropanoic acid; TUG 891; TUG891

CAS Number: 1374516-07-0
Empirical Formula (Hill Notation): C23H21FO3
Molecular Weight: 364.41
Linear Formula: C23H21FO3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1914-5MG 5 mg
 $116.00
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45-SML1914-25MG 25 mg
 $467.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C23H21FO3/c1-16-2-7-18(8-3-16)22-12-9-20(24)14-19(22)15-27-21-10-4-17(5-11-21)6-13-23(25)26/h2-5,7-12,14H,6,13,15H2,1H3,(H,25,26)
InChI key LPGBXHWIQNZEJB-UHFFFAOYSA-N
Quality Level 100 
SMILES string Fc1cc(c(cc1)c3ccc(cc3)C)COc2ccc(cc2)CCC(=O)O
solubility DMSO: 20 mg/mL, clear
storage temp. room temp
Biochem/physiol Actions: Orally active, potent and selective agonist for long chain free fatty acid (FFA) receptor FFA4 (GPR120).
Biochem/physiol Actions: TUG-891 is an orally active, potent and selective agonist for human long chain free fatty acid (FFA) receptor FFA4/GPR120 (pEC50 of receptor β-arrestin-2 recruitment = 7.36/FFA4 vs. 4.19/FFA1 HEK transfectants; pEC50 of calcium mobilization = 7.02/FFA4 vs. 5.30/FFA1 transfectants), while exhibiting no activity toward human short-chain FFA receptors FFA2/GPR43 and FFA3/GPR41. TUG-891 also exhibits potent partial agonist activity toward murine FFA4 (pEC50 = 7.77, 75% efficacy by β-arrestin-2 recruitment assay; pEC50 = 6.89 by calcium mobilization), albeit with a reduced selectivity over mFFA1 (pEC50 = 5.92 by β-arrestin-2 recruitment and 6.41 by by calcium mobilization). When administered via water intake (~20 mg/kg/day), TUG-891 is reported to reverse food intake increases and body weight gains among mice subjected to sleep fragmentation, and significantly attenuate visceral white adipose tissue inflammation as well as insulin resistance.
Biochem/physiol Actions: TUG-891, a GPR120 agonist helps to stimulate metabolic health by inducing mitochondrial respiration in brown fat. It is capable of enhancing lipid oxidation and decreasing fat mass in mice.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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