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Marizomib

SIGMA/SML1916 - ≥95% (HPLC), (Salinospora tropica)

Synonym: (1R,4R,5S)-4-(2-Chloroethyl)-1-[(S)-(1S)-2-cyclohexen-1-ylhydroxymethyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione; NPI-0052; Salinosporamide A

CAS Number: 437742-34-2
Empirical Formula (Hill Notation): C15H20ClNO4
Molecular Weight: 313.78
Linear Formula: C15H20ClNO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1916-100UG 100 µg
 $190.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥95% (HPLC)
biological source (Salinospora tropica)
color white to beige
form powder
InChI 1S/C15H20ClNO4/c1-14-10(7-8-16)12(19)17-15(14,13(20)21-14)11(18)9-5-3-2-4-6-9/h3,5,9-11,18H,2,4,6-8H2,1H3,(H,17,19)/t9-,10+,11+,14+,15+/m1/s1
InChI key NGWSFRIPKNWYAO-SHTIJGAHSA-N
Quality Level 100 
shipped in wet ice
SMILES string ClCC[C@@H]1[C@@]2(OC(=O)[C@@]2(NC1=O)[C@@H](O)[C@H]3CCCC=C3)C
storage condition desiccated
storage temp. −20°C
Application: Marizomib has been used as a proteasome inhibitor:
• to study its effects on glioblastoma cell lines
• to analyze its effects on the aging of killifish brain
• to test its effect on protein kinase B (PKB/AKT) levels in multiple myeloma cells
Biochem/physiol Actions: Marizomib a natural product is a marine-derived β-lactone-γ-lactam. It shows therapeutic effects against hematologic and solid tumor malignancies.. It is involved in the activation of caspase-3,-8, and -9, increases the reactive oxygen species (ROS) and promotes apoptosis. Marizomib can cross the blood-brain barrier and might have the potential to treat primary brain tumors. It possesses anti-tumor properties.
Biochem/physiol Actions: Marizomib is a second generation proteasome inhibitor with anti-cancer activity.
Biochem/physiol Actions: Marizomib is a second generation proteasome inhibitor with anti-cancer activity. Marizomib binds irreversibly and potently inhibits all three 20S proteasome subunits.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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