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ML349

SIGMA/SML1918 - ≥98% (HPLC)

Synonym: ML349; (5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone; ML 349; ML-349; (5,5-Dioxo-4H-thieno[4,5-c]thiochromen-2-yl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone

CAS Number: 890819-86-0
Empirical Formula (Hill Notation): C23H22N2O4S2
Molecular Weight: 454.56
Linear Formula: C23H22N2O4S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1918-5MG 5 mg
 $116.00
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45-SML1918-25MG 25 mg
 $467.00
1/EA		 Add To Favorites
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This image depicts SML1918-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C23H22N2O4S2/c1-29-18-8-6-17(7-9-18)24-10-12-25(13-11-24)23(26)20-14-16-15-31(27,28)21-5-3-2-4-19(21)22(16)30-20/h2-9,14H,10-13,15H2,1H3
InChI key YVIJPELUPZUEJX-UHFFFAOYSA-N
Quality Level 100 
SMILES string [S]1(=O)(=O)Cc2c([s]c(c2)C(=O)N4CCN(CC4)c5ccc(cc5)OC)c3c1cccc3
solubility DMSO: 3 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: ML349 is a substrate-competitive, reversible and APT2-selective acyl-protein thioesterase (APT) inhibitor (IC50/Ki = 510 nM/230 nM against APT2; IC50 & Ki >10 μM against APT1). ML349 effectively inhibits cellular APT2 activity in cultures (by >95% in HEK293T & mouse T cells; 5 μM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT1. ML349 treatment (5 μM) is shown to restore palmitoylation and membrane localization of the multidomain scaffolding protein Scribble (Scrib) in MDCK cells overexpressing the epithelial-to-mesenchymal transcription factor (EMT-TF) Snail.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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