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NVP-ADW742

SIGMA/SML1921 - ≥98% (HPLC)

Synonym: 5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine; NVP-ADW 742

CAS Number: 475488-23-4
Empirical Formula (Hill Notation): C28H31N5O
Molecular Weight: 453.58
Linear Formula: C28H31N5O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1921-5MG 5 mg
 $98.40
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45-SML1921-25MG 25 mg
 $397.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(15-22)34-18-20-7-2-1-3-8-20)17-33(28(26)31-19-30-27)23-13-21(14-23)16-32-11-4-5-12-32/h1-3,6-10,15,17,19,21,23H,4-5,11-14,16,18H2,(H2,29,30,31)/t21-,23-
InChI key LSFLAQVDISHMNB-AFARHQOCSA-N
Quality Level 100 
SMILES string N6(CCCC6)C[C@@H]1C[C@H](C1)[n]2c3ncnc(c3c(c2)c4cc(ccc4)OCc5ccccc5)N
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Application: NVP-ADW742 has been used as an insulin-like growth factor 1 receptor (IGF1R) inhibitor to test the effects of filamin A (FLNA) silencing in a cell proliferation assay.
Biochem/physiol Actions: Insulin-like growth factor-I (IGF-I) receptor kinase inhibitor
Biochem/physiol Actions: NVP-ADW742 is a potent and selective ATP-competitive inhibitor of Insulin-like growth factor-I receptor (IGF-IR) kinase. NVP-ADW742 sensitizes cancer cell lines to multiple anticancer agents including etoposide, carboplatin, imatinib, vincristine, and doxorubicin.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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