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A-395 hydrochloride

SIGMA/SML1923 - ≥98% (HPLC)

Synonym: (3R,4S)-1-(7-Fluoro-2,3-dihydro-1H-inden-1-yl)-4-{4-[4-(methanesulfonyl)piperazin-1-yl]phenyl}-N,N-dimethylpyrrolidin-3-amine hydrochloride

CAS Number: 2089148-72-9
Empirical Formula (Hill Notation): C26H35FN4O2S · xHCl
Molecular Weight: 486.65 (free base basis)
MDL Number: MFCD31563589
Linear Formula: C26H35FN4O2S · xHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1923-5MG 5 mg
 $194.00
1/EA		 Add To Favorites
45-SML1923-25MG 25 mg
 $584.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C26H35FN4O2S/c1-28(2)25-18-30(24-12-9-20-5-4-6-23(27)26(20)24)17-22(25)19-7-10-21(11-8-19)29-13-15-31(16-14-29)34(3,32)33/h4-8,10-11,22,24-25H,9,12-18H2,1-3H3/t22-,24?,25+/m1/s1
InChI key REVJNSVNICWODC-KIDMSAQOSA-N
Quality Level 100 
SMILES string FC1=CC=CC2=C1C(N3C[C@H](C(C=C4)=CC=C4N5CCN(S(C)(=O)=O)CC5)[C@@H](N(C)C)C3)CC2
solubility H2O: 10 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: A-395 is a potent and selective chemical probe for the polycomb protein EED (embryonic ectoderm development), an essential component of Polycomb repressive complex 2 (PRC2), involved in transcriptional repression through methylation of histone H3K27. A-395 has been found to bind to EED in vitro with a Ki value of 0.4 nM, inhibit the PRC2 complex with an IC50 value 34 nM for methylation of H3K27, and have >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In RD rhabdoid tumor cell line A-395 inhibited the PRC2 complex with an IC50 value of 90 nM, inhibiting the formation of H3K27me3. For characterization details of A-395, please visit the A-395 probe summary  on the Structural Genomics Consortium (SGC) website.

A-395N is the negative control for the active enantiomer, A-395. A-395N is available from Sigma. To learn more about and purchase A-395N, click here .

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc 
Biochem/physiol Actions: Potent and selective chemical probe for EED
Features and Benefits: A-395 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC .
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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