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Bepristat 2a hydrochloride

SIGMA/SML1925 - ≥95% (HPLC)

Synonym: 6-Bromo-2-[[[2-(diethylamino)ethyl]amino]methyl]-5-hydroxy-1-phenyl-1H-indole-3-carboxylic acid ethyl ester hydrochloride

CAS Number: 2140803-90-1
Empirical Formula (Hill Notation): C24H30BrN3O3 · xHCl
Molecular Weight: 488.42 (free base basis)
Linear Formula: C24H30BrN3O3 · xHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1925-5MG 5 mg
 $129.00
1/EA		 Add To Favorites
45-SML1925-25MG 25 mg
 $525.00
1/EA		 Add To Favorites

 

assay ≥95% (HPLC)
color white to beige
form powder
InChI key HKOKWSVFJJFYDV-UHFFFAOYSA-N
Quality Level 100 
SMILES string CCN(CC)CCNCC1=C(C(OCC)=O)C2=CC(O)=C(Br)C=C2N1C3=CC=CC=C3.[H]Cl
solubility H2O: 10 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: Bepristat 2a is a selective reversible inhibitor of protein disulfide isomerase (PDI), an enzyme in the endoplasmic reticulum that catalyzes disulfide bond breakage and reformation to catalyze protein folding. Unlike most PDI inhibitors, Bepristat 2a binds at the substrate-binding site, rather than the catalytic site. Bepristat 2a blocked PDI activity with an IC50 value of 1200 nM, while enhancing catalytic activity of remote PDI domains. PDI is up-regulated in several cancers, has been implicated in neurodegenerative processes, and plays an important role in thrombus formation. Bepristat 2a potently inhibited platelet aggregation and thrombus formation in vivo.
Biochem/physiol Actions: Bepristat 2a is a selective reversible inhibitor of protein disulfide isomerase (PDI).
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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