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CORM-401

SIGMA/SML1930

Synonym: Mn(CO)4{S2CNMe(CH2CO2H)}; Tetracarbonyl[N-(dithiocarboxy-?S,?S′)-N-methylglycine]manganate

CAS Number: 1001015-18-4
Empirical Formula (Hill Notation): C8H6MnNO6S2
Molecular Weight: 331.20
Linear Formula: C8H6MnNO6S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1930-5MG 5 mg
 $116.00
1/EA		 Add To Favorites
45-SML1930-25MG 25 mg
 $467.00
1/EA		 Add To Favorites

 

color light yellow to dark yellow
form powder
Quality Level 100 
SMILES string CN(CC(O)=O)C1=S=[Mn-4]([C+]=O)([C+]=O)([C+]=O)([C+]=O)S1
solubility DMSO: 10 mg/mL, clear
storage condition protect from light
storage temp. −20°C
Biochem/physiol Actions: CORM-401 (Mn(CO)4(S2CNMe(CH2CO2H))) is a manganese-containing carbon monoxide-releasing molecule (CORM) that generates at least three molar equivalents of CO. Due to reversible binding of CO, CORM-401 is relatively stable in solution (0.33 mol eq of CO loss after 4 h in PBS; [CORM-401] = 1 mM at time zero), while increased CO release occurs in the presence of a CO receptor or a ligand to prevent the rebinding of CO (3.2 mol eq of CO transferred to iron with a t1/2 of 0.8 min in the presence of 44 μM myoglobin; [CORM-401] = 10 μM at time zero). CO administration by CORM-401 is reported to uncouple mitochondrial respiration and inhibit glycolysis in human endothelial cells (10-100 μM), and relax isolated rat aortic rings (25 μM) pre-contracted with phenylephrine.
Biochem/physiol Actions: Mn-containing carbon monoxide-releasing molecule (CORM) that generates three-times more CO than CORM-A1 and CORM-3.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Storage Temp. −20°C
UNSPSC 12352200

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