LY450139

SIGMA/SML1938 - ≥98% (HPLC)

Synonym: (2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]-butanamide; LY 450139; LY-450139; Semagacestat

CAS Number: 425386-60-3
Empirical Formula (Hill Notation): C₁₉H₂₇N₃O₄
Molecular Weight: 361.44
MDL Number: MFCD09970409
Linear Formula: C₁₉H₂₇N₃O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1938-5MG	5 mg	$129.00 1/EA	Add To Favorites
45-SML1938-25MG	25 mg	$525.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C19H27N3O4/c1-11(2)16(23)18(25)20-12(3)17(24)21-15-14-8-6-5-7-13(14)9-10-22(4)19(15)26/h5-8,11-12,15-16,23H,9-10H2,1-4H3,(H,20,25)(H,21,24)/t12-,15-,16-/m0/s1
InChI key	PKXWXXPNHIWQHW-RCBQFDQVSA-N
Quality Level	100
SMILES string	O=C([C@@H](NC([C@@H](O)C(C)C)=O)C)N[C@@H](C1=CC=CC=C1CCN2C)C2=O
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	LY450139 (Semagacestat) is a notch-sparing, potent and selective gamma-secretase inhibitor. LY450139 lowers plasma and cerebrospinal fluid Aβ in humans.
Biochem/physiol Actions:	Notch-sparing, potent and selective gamma-secretase inhibitor and inverse modulator of Aβ

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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