Synonym: 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
CAS Number: 216691-95-1
Empirical Formula (Hill Notation): C27H21ClN2O2
Molecular Weight: 440.92
MDL Number: MFCD30536363
Linear Formula: C27H21ClN2O2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C27H21ClN2O2/c1-30-25-13-10-21(28)16-23(25)26(19-8-11-22(31)12-9-19)29-24(27(30)32)15-17-6-7-18-4-2-3-5-20(18)14-17/h2-14,16,24,29H,15H2,1H3 |
| InChI key |
IJEUIRDNQUQMFU-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
ClC1=CC=C2C(C(C3=CC=C(O)C=C3)=NC(CC4=CC=C(C=CC=C5)C5=C4)C(N2C)=O)=C1 |
| solubility |
DMSO: 2 mg/mL, clear |
| storage temp. |
2-8°C |
| Application: |
Bz-423 has been used as a mitochondrial inner membrane pore (MIMP) reagent to study its effect on oxygen consumption rate (OCR) and ATP synthesis in HepG2 cells. |
| Biochem/physiol Actions: |
Bz-423 is an inhibitor of mitochondrial F1F0 ATP synthase. It binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase, resulting in superoxide generation and apoptosis. BZ-423 was shown to block multidrug-resistant melanoma cells. In another study, Bz-423 selectively increased superoxide and induced the apoptosis of alloreactive T cells, which arrested established Graft versus Host Disease. |
| Biochem/physiol Actions: |
Bz-423 stimulates mitochondrial inner membrane pore (MIMP) opening in isolated mitochondria. |
| Biochem/physiol Actions: |
Inhibitor of mitochondrial F1F0-ATP synthase |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
