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Bz-423

SIGMA/SML1944 - ≥98% (HPLC)

Synonym: 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one

CAS Number: 216691-95-1
Empirical Formula (Hill Notation): C27H21ClN2O2
Molecular Weight: 440.92
MDL Number: MFCD30536363
Linear Formula: C27H21ClN2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1944-5MG 5 mg
 $116.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C27H21ClN2O2/c1-30-25-13-10-21(28)16-23(25)26(19-8-11-22(31)12-9-19)29-24(27(30)32)15-17-6-7-18-4-2-3-5-20(18)14-17/h2-14,16,24,29H,15H2,1H3
InChI key IJEUIRDNQUQMFU-UHFFFAOYSA-N
Quality Level 100 
SMILES string ClC1=CC=C2C(C(C3=CC=C(O)C=C3)=NC(CC4=CC=C(C=CC=C5)C5=C4)C(N2C)=O)=C1
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Application: Bz-423 has been used as a mitochondrial inner membrane pore (MIMP) reagent to study its effect on oxygen consumption rate (OCR) and ATP synthesis in HepG2 cells.
Biochem/physiol Actions: Bz-423 is an inhibitor of mitochondrial F1F0 ATP synthase. It binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase, resulting in superoxide generation and apoptosis. BZ-423 was shown to block multidrug-resistant melanoma cells. In another study, Bz-423 selectively increased superoxide and induced the apoptosis of alloreactive T cells, which arrested established Graft versus Host Disease.
Biochem/physiol Actions: Bz-423 stimulates mitochondrial inner membrane pore (MIMP) opening in isolated mitochondria.
Biochem/physiol Actions: Inhibitor of mitochondrial F1F0-ATP synthase
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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