S1QEL1.1

SIGMA/SML1948 - ≥98% (HPLC)

Synonym: N1-(3-acetamidophenyl)-N2-(2-(4-methyl-2-(p-tolyl)thiazol-5-yl)ethyl)oxalamide; S1QEL

CAS Number: 897613-29-5
Empirical Formula (Hill Notation): C₂₃H₂₄N₄O₃S
Molecular Weight: 436.53
Linear Formula: C₂₃H₂₄N₄O₃S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1948-5MG	5 mg	$129.00 1/EA		Add To Favorites
45-SML1948-25MG	25 mg	$525.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C23H24N4O3S/c1-14-7-9-17(10-8-14)23-25-15(2)20(31-23)11-12-24-21(29)22(30)27-19-6-4-5-18(13-19)26-16(3)28/h4-10,13H,11-12H2,1-3H3,(H,24,29)(H,26,28)(H,27,30)
InChI key	BFNBJUBXXJKBFN-UHFFFAOYSA-N
Quality Level	100
shipped in	wet ice
SMILES string	CC1=C(CCNC(C(NC2=CC=CC(NC(C)=O)=C2)=O)=O)SC(C3=CC=C(C)C=C3)=N1
solubility	DMSO: 2 mg/mL, clear
storage temp.	−20°C

Application:	S1QEL1.1 has been used as a reverse electron transport (RET)-induced mitochondrial (mito) reactive oxygen species (ROS) suppressor: • to investigate the role of mitochondrial-derived superoxide in triggering ferroptosis • to study the mechanism involved in the regulation of anti-fungal responses of macrophages against Aspergillus infection • in combination with mito-antioxidant to study their influence on mitochondria-derived H₂O₂ in cancer cells • to determine the effect of oxidative stress depletion on myoblast differentiation
Biochem/physiol Actions:	S1QEL1.1 is a suppressor of mitochondrial respiratory complex I site IQ electron leak, suppressing superoxide and/or H₂O₂ production without altering oxidative phosphorylation. S1QEL1.1 had an IC50 values of 70 nM against superoxide-H₂O₂ production from site IQ. It decreased caspase activation in a in a cardiomyocyte cell model of ER stress and decreased ischemia-reperfusion injury in the Langendorff-perfused mouse heart model.
Biochem/physiol Actions:	Suppressor of mitochondrial respiratory complex I site IQ electron leak, suppressing superoxide and/or H2O2 production without altering oxidative phosphorylation
Biochem/physiol Actions:	Suppressors of the site IQ electron leak (S1QEL)1.1 reduces cytokine secretion and fungicidal activity of macrophages infected with swollen A. fumigatus conidia by suppressing reverse electron transport (RET)-induced mitochondrial reactive oxygen species (ROS).

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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