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Synta66

SIGMA/SML1949 - ≥98% (HPLC)

Synonym: 4-Pyridinecarboxamide, N-(2′,5′-dimethoxy[1,1′-biphenyl]-4-yl)-3-fluoro-; GSK1349571A; N-(2′,5′-Dimethoxy[1,1′-biphenyl]-4-yl)-3-fluoro-4-pyridinecarboxamide; S66; Synta 66; Synta-66

CAS Number: 835904-51-3
Empirical Formula (Hill Notation): C20H17FN2O3
Molecular Weight: 352.36
Linear Formula: C20H17FN2O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1949-5MG 5 mg
 $121.00
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45-SML1949-25MG 25 mg
 $467.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI key GFEIWXNLDKUWIK-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(NC1=CC=C(C2=C(OC)C=CC(OC)=C2)C=C1)C3=CC=NC=C3F
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Application: Synta66 has been used:
• as a Ca2+ release-activated calcium (CRAC) channel inhibitor to study its effects on ORAI isoforms
• as an ORAI1 blocker to study its effects on the entry of Ca2+ in chronic lymphocytic leukemia (CLL) B cells
• as a CRAC blocker to study its effects on the influx of Ca2+ by store-operated Ca2+ entry (SOCE) in enamel cells
Biochem/physiol Actions: A selective SOCE inhibitor that blocks CRAC current (ICRAC) without significant off-target potency or affinity.
Biochem/physiol Actions: Synta66 (S66) is a CRAC (Ca2+ release-activated Ca2+) channel inhibitor that blocks SOCE (store-operated Ca2+ entry) upon Ca2+ depletion from intracellular stores by thapsigargin in human vascular smooth muscle cells (VSMCs) with high potency (IC50 = 26 nM & 43 nM based on maximum Ca2+ level & rate of increase, respectly). Synta66 exhibits no affinity toward a range of receptors and ion channels (e.g. L-type Ca2+ channel) and does not affect TRPC1/5-mediated SOCE or store-operated non-selective cationic current. Leukocytes are reported to be less sensitive to CRAC inhibition by Synta66 (IC50 = 1.76 μM/HL-60, 1 ?M/Jurkat, 1.4 μM/rat RBL).
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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