X-34

SIGMA/SML1954 - ≥90% (HPLC)

Synonym: 1,4-Bis(3-carboxy-4-hydroxyphenylethenyl)benzene

CAS Number: 215294-98-7
Empirical Formula (Hill Notation): C₂₄H₁₈O₆
Molecular Weight: 402.40
MDL Number: MFCD30474509
Linear Formula: C₂₄H₁₈O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1954-5MG	5 mg	$116.00 1/EA		Add To Favorites
45-SML1954-25MG	25 mg	$467.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (HPLC)
color	white to beige
form	powder
InChI	1S/C24H18O6/c25-21-11-9-17(13-19(21)23(27)28)7-5-15-1-2-16(4-3-15)6-8-18-10-12-22(26)20(14-18)24(29)30/h1-14,25-26H,(H,27,28)(H,29,30)
InChI key	MCBNOAYTZBUCSX-UHFFFAOYSA-N
Quality Level	100
SMILES string	OC(C=C1)=C(C(O)=O)C=C1C=CC2=CC=C(C=CC3=CC=C(O)C(C(O)=O)=C3)C=C2
solubility	DMSO: 2.0 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	Fluorescent, amyloid-specific dye
Biochem/physiol Actions:	X-34 (1,4-bis(3-carboxy-4-hydroxyphenylethenyl)-benzene) is one among the small-molecule γ-secretase modulators (GSMs) involved in lowering Aβ42 levels (the 42-residue isoform of the amyloid-β peptide). X-34 has also been used to visualize intracellular immunoreactive deposits with classic amyloid fibrillar ultrastructure in living transgenic Caenorhabditis elegans animals. It is also used as a histochemical stain for determining pathological changes in Alzheimer′s disease (AD).
Biochem/physiol Actions:	X-34 is a fluorescent, amyloid-specific dye. It binds at a different site than Pittsburgh Compound B and is a highly fluorescent marker for beta-sheet structures.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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