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PKUMDL-WQ-2201

SIGMA/SML1965 - ≥98% (HPLC)

Synonym: 2-Chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]-benzoic acid

CAS Number: 592474-91-4
Empirical Formula (Hill Notation): C15H14ClN3O3S
Molecular Weight: 351.81
Linear Formula: C15H14ClN3O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1965-5MG 5 mg
 $116.00
1/EA		 Add To Favorites
45-SML1965-25MG 25 mg
 $467.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to brown
form powder
InChI 1S/C15H14ClN3O3S/c1-2-17-15(23)19-18-8-10-4-6-13(22-10)9-3-5-11(14(20)21)12(16)7-9/h3-8H,2H2,1H3,(H,20,21)(H2,17,19,23)
InChI key XPACBFAEZIPDRT-UHFFFAOYSA-N
SMILES string O=C(C(C=CC(C1=CC=C(C=NNC(NCC)=S)O1)=C2)=C2Cl)O
solubility DMSO: 15 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: PKUMDL-WQ-2201 is a potent and selective non-NAD+-competing allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) that selectively inhibits serine synthesis in cancer cells. PKUMDL-WQ-2201 binds to allosteric site II, which is located in the substrate-binding domain. PKUMDL-WQ-2201 inhibits tumor growth of MDA-MB-468 xenografts in mice.
Biochem/physiol Actions: Potent and selective non-NAD+-competing allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH)
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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