SK609 hydrochloride
SIGMA/SML1966 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 1092797-77-7
Empirical Formula (Hill Notation): C10H14ClN · HCl
Molecular Weight: 220.14
Linear Formula: C10H14ClN · HCl
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| solubility | H2O: 2 mg/mL, clear |
| storage condition | protect from light |
| under inert gas | |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | Dopamine D3 receptor (D3R) selective agonist |
| Biochem/physiol Actions: | SK609 (ES609) is a Dopamine D3 receptor (D3R) selective agonist with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation. SK609 has been shown to reverse akinesia and reduce L-dopa-induced dyskinesia in a hemiparkinsonian rat model of Parkinson′s desease. It does not induce desensitization of D3R. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352202 |