LLY-284

SIGMA/SML1971 - ≥98% (HPLC)

Synonym: (2R,3R,4S,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-hydroxy(phenyl)methyl)tetrahydrofuran-3,4-diol; (S)-5′-phenyl-7-deazaadenosine; 6-amino-9-[(S)-5′-phenyl(ribofuranosyl)]-7-deazapurine; LLY 284; LLY284

CAS Number: 2226515-75-7
Empirical Formula (Hill Notation): C₁₇H₁₈N₄O₄
Molecular Weight: 342.35
Linear Formula: C₁₇H₁₈N₄O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1971-5MG	5 mg	$285.00 1/EA	Add To Favorites
45-SML1971-25MG	25 mg	$883.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI key	WWOOWAHTEXIWBO-CNUKPYSBSA-N
SMILES string	O[C@@H]1[C@@H]([C@@H](O)C2=CC=CC=C2)O[C@@H](N3C(N=CN=C4N)=C4C=C3)[C@@H]1O
storage temp.	2-8°C

Biochem/physiol Actions:	Less potent diastereomer and control compound for the potent and selective SAM-competitive PRMT5 inhibitor LLY-283.
Biochem/physiol Actions:	LLY-284 is the less potent diastereomer of the potent SAM-competitive PRMT5 inhibitor LLY-283 (IC50 = 20 nM against PRMT5-catalyzed methylation of an H4R3-derived peptide substrate) and an ideal control compound for cellular studies. For characterization details of the active probe, LLY-283, please visit the LLY-283 probe summary on the Structural Genomics Consortium (SGC) website. LLY-283, the active probe, is available from Sigma. To learn more about and purchase LLY-283, click here . To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Features and Benefits:	LLY-284 is a negative control for LLY-283, an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC .

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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