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LLY-283

SIGMA/SML1972 - ≥98% (HPLC)

Synonym: (2R,3R,4S,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-hydroxy(phenyl)methyl)tetrahydrofuran-3,4-diol; (R)-5′-phenyl-7-deazaadenosine; 6-amino-9-[(R)-5′-phenyl(ribofuranosyl)]-7-deazapurine; LLY 283; LLY283

CAS Number: 2040291-27-6
Empirical Formula (Hill Notation): C17H18N4O4
Molecular Weight: 342.35
Linear Formula: C17H18N4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1972-5MG 5 mg
 $246.00
1/EA		 Add To Favorites
45-SML1972-25MG 25 mg
 $619.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI key WWOOWAHTEXIWBO-QFRSUPTLSA-N
SMILES string O[C@@H]1[C@@H]([C@H](O)C2=CC=CC=C2)O[C@@H](N3C(N=CN=C4N)=C4C=C3)[C@@H]1O
storage temp. 2-8°C
Biochem/physiol Actions: A potent and selective SAM-competitive PRMT5 inhibitor.
Biochem/physiol Actions: LLY-283 is a potent and selective SAM-competitive PRMT5 inhibitor (IC50 = 20 nM against PRMT5-catalyzed methylation of an H4R3-derived peptide substrate) with greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. LLY-283 inhibits Smith (Sm) antigen SmBB’ methylation in MCF7 cells (IC50 = 25 nM; 3 days) and affects MDM4 splicing in A375 cells (IC50 = 40 nM; 3 days). The diastereomer LLY-284 is less potent in the biochemical assay and is an ideal control compound for cellular studies. For characterization details of LLY-283, please visit the LLY-283 probe summary  on the Structural Genomics Consortium (SGC) website.

LLY-284 is the negative control for the active probe, LLY-283. LLY-284 is available from Sigma. To learn more about and purchase LLY-284, click here .

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc 
Features and Benefits: LLY-283 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC .
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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