Synonym: 9H-Carbazole-9-ethanamine, N,N-diethyl-3,6-dinitro- trifluoroacetate; Curaxin CBLC000 trifluoroacetate; N,N-Diethyl-3,6-dinitro-9H-carbazole-9-ethanamine trifluoroacetate
CAS Number: 324780-02-1 (free base)
Empirical Formula (Hill Notation): C18H20N4O4 · C2HF3O2
Molecular Weight: 470.40
Linear Formula: C18H20N4O4 · C2HF3O2
Product Type: Chemical
| assay |
≥95% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C18H20N4O4.C2HF3O2/c1-3-19(4-2)9-10-20-17-7-5-13(21(23)24)11-15(17)16-12-14(22(25)26)6-8-18(16)20;3-2(4,5)1(6)7/h5-8,11-12H,3-4,9-10H2,1-2H3;(H,6,7) |
| InChI key |
VFGJIBCWHYFSHE-UHFFFAOYSA-N |
| SMILES string |
CCN(CC)CCN1C2=C(C=C([N+]([O-])=O)C=C2)C3=C1C=CC([N+]([O-])=O)=C3.FC(F)(C(O)=O)F |
| solubility |
DMSO: 2 mg/mL, clear |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
CBLC000 is a potent inhibitor of FACT (facilitates chromatin transcription) complex that activates p53 and suppresses NF-kB without genotoxicity. CBLC000 induces chromatin trapping of FACT both in vitro and in vivo. CBLC000 exhibits brad anticancer activity. CBLC000 analog clinical candidate CBL0137 decreases self-renewal of GBM stem cells (GSC). |
| Biochem/physiol Actions: |
Potent inhibitor of FACT complex that activates p53 and suppresses NF-kB without genotoxicity |
| Purity |
≥95% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
GHS07