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DIM-C-pPhCO2Me

SIGMA/SML1976 - ≥98% (HPLC)

Synonym: 4-(di-1H-Indol-3-ylmethyl)-benzoic acid methyl ester; Benzoic acid, 4-(di-1H-indol-3-ylmethyl)-, methyl ester

CAS Number: 151358-48-4
Empirical Formula (Hill Notation): C25H20N2O2
Molecular Weight: 380.44
Linear Formula: C25H20N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1976-25MG 25 mg
 $742.00
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This image depicts SML1976-25MG.

 

assay ≥98% (HPLC)
color pink to light red
form powder
InChI 1S/C25H20N2O2/c1-29-25(28)17-12-10-16(11-13-17)24(20-14-26-22-8-4-2-6-18(20)22)21-15-27-23-9-5-3-7-19(21)23/h2-15,24,26-27H,1H3
InChI key BBAOKSZCULLDIW-UHFFFAOYSA-N
SMILES string O=C(OC)C1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=CC=CC=C54)C=C1
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: DIM-C-pPhCO2Me is a NR4A1 (Nur77) antagonist that exhibit potent anticancer activity in pancreatic, colon, breast, kidney, and rhabdomyosarcoma cells. DIM-C-pPhCO2Me decreases expression of PAX3-FOXO1A and β1-integrin proteins in Rh30 rhabdomyosarcoma and MDA-MB-231 breast cancer cells. DIM-C-pPhCO2Me inhibits migration of Rh30 and MDA-MB-231 cancer cells.
Biochem/physiol Actions: DIM-C-pPhCO2Me is also known as 1,1-bis(3′-indolyl)-1-(p-carboxymethylphenyl)methane. In pancreatic and colon cancer cells, DIM-C-pPhCO2Me plays an inhibitory role on cell migration. DIM-C-pPhCO2Me prevents the action of mechanistic target of rapamycin (mTOR) and reduces the multiplication and survival of cancer cells. It stimulates reactive oxygen species (ROS) in various cancer cell lines.
Biochem/physiol Actions: NR4A1 (Nur77) antagonist that exhibit potent anticancer activity
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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