DIM-C-pPhCO2Me

SIGMA/SML1976 - ≥98% (HPLC)

Synonym: 4-(di-1H-Indol-3-ylmethyl)-benzoic acid methyl ester; Benzoic acid, 4-(di-1H-indol-3-ylmethyl)-, methyl ester

CAS Number: 151358-48-4
Empirical Formula (Hill Notation): C₂₅H₂₀N₂O₂
Molecular Weight: 380.44
Linear Formula: C₂₅H₂₀N₂O₂
Product Type: Chemical

assay	≥98% (HPLC)
color	pink to light red
form	powder
InChI	1S/C25H20N2O2/c1-29-25(28)17-12-10-16(11-13-17)24(20-14-26-22-8-4-2-6-18(20)22)21-15-27-23-9-5-3-7-19(21)23/h2-15,24,26-27H,1H3
InChI key	BBAOKSZCULLDIW-UHFFFAOYSA-N
SMILES string	O=C(OC)C1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=CC=CC=C54)C=C1
solubility	DMSO: 2 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	DIM-C-pPhCO2Me is a NR4A1 (Nur77) antagonist that exhibit potent anticancer activity in pancreatic, colon, breast, kidney, and rhabdomyosarcoma cells. DIM-C-pPhCO2Me decreases expression of PAX3-FOXO1A and β1-integrin proteins in Rh30 rhabdomyosarcoma and MDA-MB-231 breast cancer cells. DIM-C-pPhCO2Me inhibits migration of Rh30 and MDA-MB-231 cancer cells.
Biochem/physiol Actions:	DIM-C-pPhCO₂Me is also known as 1,1-bis(3′-indolyl)-1-(p-carboxymethylphenyl)methane. In pancreatic and colon cancer cells, DIM-C-pPhCO₂Me plays an inhibitory role on cell migration. DIM-C-pPhCO₂Me prevents the action of mechanistic target of rapamycin (mTOR) and reduces the multiplication and survival of cancer cells. It stimulates reactive oxygen species (ROS) in various cancer cell lines.
Biochem/physiol Actions:	NR4A1 (Nur77) antagonist that exhibit potent anticancer activity

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable