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PSB-603

SIGMA/SML1983 - ≥98% (HPLC)

Synonym: 8-(4-(4-(4-Chlorophenyl)piperazide-1-sulfonyl)phenyl)-1-propylxanthine; 8-[4-[[4-(4-Chlorophenyl)-1-piperazinyl]sulfonyl]phenyl]-3,9-dihydro-1-propyl-1H-purine-2,6-dione; PSB 603; PSB603

CAS Number: 1092351-10-4
Empirical Formula (Hill Notation): C24H25ClN6O4S
Molecular Weight: 529.01
Linear Formula: C24H25ClN6O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1983-5MG 5 mg
 $145.00
1/EA		 Add To Favorites
45-SML1983-25MG 25 mg
 $584.00
1/EA		 Add To Favorites
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This image depicts SML1983-25MG.

 

assay ≥98% (HPLC)
color white to brownish
form powder
InChI 1S/C24H25ClN6O4S/c1-2-11-31-23(32)20-22(28-24(31)33)27-21(26-20)16-3-9-19(10-4-16)36(34,35)30-14-12-29(13-15-30)18-7-5-17(25)6-8-18/h3-10H,2,11-15H2,1H3,(H,26,27)(H,28,33)
InChI key OVHCTHHFOHMNFV-UHFFFAOYSA-N
shipped in ambient
SMILES string O=C(N1CCC)NC2=C(N=C(C3=CC=C(S(=O)(N4CCN(C5=CC=C(Cl)C=C5)CC4)=O)C=C3)N2)C1=O
solubility DMSO: 2 mg/mL to clear
storage temp. 2-8°C
Biochem/physiol Actions: A high-affinity, selective antagonist against A2b adenosine receptor (A2b-AR, A2bR).
Biochem/physiol Actions: PSB-603 is an adenosine receptor A2b antagonist (IC50 = 1.13 nM against 10 μM A2bR agonist NECA-induced calcium response in Jurkat T cells in the presence of 200 nM A2aR antagonist MSX-2) that targets A2bR with high affinity (KD = 0.403 nM/human, 0.457 nM/rat, 4.09 nM/mouse A2bR; Ki against 0.3 nM [3H]PSB-603 = 0.553 nM/human, 0.355 nM/rat, 0.265 nM/mouse A2bR) and selectivity, exhibiting little affinity toward A1, A2a, or A3 adenosine receptors by competition binding assay (Ki >10 μM against 0.4 nM [3H]DPCPX for human/rat A1R, 1 nM [3H]MSX-2 for human/mouse/rat A2aR, 10 nM [3H]NECA for human/mouse/rat A3R) with the exception of mouse A1R (Ki = 42.2 nM against 0.4 nM [3H]DPCPX).
Biochem/physiol Actions: PSB-603 is known to modify cellular metabolism and enhance cellular sensitivity for chemotherapy. Thus, PSB-603 is recognized to possess anticancer action, which has been studied in colorectal cancer.
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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