GSK9311
SIGMA/SML1984 - ≥98% (HPLC)
Synonym: (R)
CAS Number: 1923851-49-3
Empirical Formula (Hill Notation): C24H31N5O3
Molecular Weight: 437.53
MDL Number: MFCD31382186
Linear Formula: C24H31N5O3
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI key | WFXIHQFRQPGCCR-MRXNPFEDSA |
| optical activity | [α]/D 90 to 100°, c = 0.3 in methanol |
| SMILES string | O=C1N(C)C2=CC(N3CCNC[C@H] |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage temp. | −20°C |
| Biochem/physiol Actions: | GSK9311 is a negative control for the SGC epigenetic probe GSK6853  . GSK9311 exhibits 125- and 185-fold reduced potency than its structural analog GSK6853 toward BRPF1 in cell-free and cell-based assays (pIC50 = 6.0/GSK9311 vs. 8.1/GSK6853 in ligand competition binding assay by TR-FRET; IC50 = 3.7 μM/GSK9311 vs. 20 nM/GSK6853 against NanoLuc-BRPF1 bromodomain interaction with Histone H3.3-HaloTag in HEK293 cells), and therefore serves as a good inactive control compound in BRPF1 inhibition studies employing GSK6853. For characterization details of the active probe, GSK6853, please visit the GSK6853 probe summary  on the Structural Genomics Consortium (SGC) website.GSK6853, the active probe, is available from Sigma. To learn more about and purchase GSK6853, click here .To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc |
| Biochem/physiol Actions: | Less potent control compound for GSK6853 in BRPF1 inhibition studies. |
| Features and Benefits: | GSK9311 is the negative control for GSK6853, an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC . |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |