TASIN-1 hydrochloride
SIGMA/SML1988 - ≥98% (HPLC)
Synonym: 1′-(4-Methoxyphenylsulfonyl)-4-methyl-1,4′-bipiperidine hydrochloride; 1,4′-Bipiperidine, 1′-[(4-methoxyphenyl)sulfonyl]-4-methyl-, hydrochloride; Truncated APC Selective INhibitor-1
CAS Number: 1678515-13-3
Empirical Formula (Hill Notation): C18H28N2O3S · HCl
Molecular Weight: 388.95
Linear Formula: C18H28N2O3S · HCl
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1988-25MG.
This image depicts SML1988-25MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI key | TXDTUQPRRXNCLP-UHFFFAOYSA |
| SMILES string | CC(CC1)CCN1C(CC2)CCN2S(C3 |
| solubility | H2O: 2 mg/mL, clear |
| storage condition | desiccated |
| protect from light | |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | EBP-dependent cholesterol synthesis inhibitor with selective cytotoxicity against colorectal cancer cells harboring APC truncations. |
| Biochem/physiol Actions: | TASIN-1 (Truncated APC Selective INhibitor-1) targets EBP- (Emopamil-binding protein; D8-D7 sterol isomerase) dependent cholesterol biosynthesis and selectively induces cellular cholesterol depletion and apoptotic death in human colorectal cancer (CRC) cultures harboring APC truncations under lipid-deficient conditions (0.2% FCS or 2% lipoprotein-deficient serum; IC50 from 35 nM/HT29 to 4.9 μM/HT55 in 72 hrs) as a result of defective cholesterol homeostasis regulation, while exhibiting little cytotoxicity toward wild-type APC CRC cells or non-transformed human colonic and bronchial epithelial cells (IC50 >50 μM in 72 hrs). TASIN-1 intraperitoneal injection is efficacious against the growth of CRC tumors with trunctated APC using the genetically engineered CPC;Apc mice (20 mg/kg twice a week) and two xenograft murine models (DLD1 & HT29; 40 mg/kg twice daily) without apparent toxicity to the animals. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |