Synonym: AR-C69931 tetrasodium salt; AR-C69931MX tetrasodium salt; N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, anhydride with P,P′-(dichloromethylene)bis[phosphonic acid]-5′-Adenylic acid tetrasodium salt
CAS Number: 163706-36-3
Empirical Formula (Hill Notation): C17H21Cl2F3N5O12P3S2·Na4
Molecular Weight: 864.29
Linear Formula: C17H21Cl2F3N5O12P3S2·Na4
Product Type: Chemical
| assay |
≥95% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C17H25Cl2F3N5O12P3S2.4Na/c1-43-5-3-23-12-9-13(26-15(25-12)44-4-2-16(20,21)22)27(7-24-9)14-11(29)10(28)8(38-14)6-37-42(35,36)39-41(33,34)17(18,19)40(30,31)32;;;;/h7-8,10-11,14,28-29H,2-6H2,1H3,(H,33,34)(H,35,36)(H,23,25,26)(H2,30,31,32);;;;/q;4*+1/p-4/t8-,10-,11-,14-;;;;/m1..../s1 |
| InChI key |
COWWROCHWNGJHQ-OPKBHZIBSA-J |
| SMILES string |
O[C@@H]1[C@H](O)[C@@H](COP(OP(C(Cl)(Cl)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)O[C@H]1N(C=N2)C3=C2C(NCCSC)=NC(SCCC(F)(F)F)=N3 |
| solubility |
H2O: 2 mg/mL, clear |
| storage temp. |
−20°C |
| Application: |
Cangrelor has been used as a purinergic receptor P2Y12 antagonist to study its effects on neuromedin U receptor 2 (NMUR2)-coupled Gαi pathway during platelet aggregation. |
| Biochem/physiol Actions: |
Cangrelor is a potent and selective platelet P2Y12 antagonist. It is used as an intravenous antiplatelet drug to prevent formation of harmful blood clots in the coronary arteries. |
| Biochem/physiol Actions: |
Cangrelor is an analog of nonthienopyridine adenosine triphosphate. It has a therapeutic effect against reversible platelet inhibition. |
| Biochem/physiol Actions: |
Potent and selective platelet P2Y12 antagonist |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥95% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
