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SMARt-420

SIGMA/SML2005 - ≥98% (HPLC)

Synonym: 1-Butanone, 4,4,4-trifluoro-1-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl); 4,4,4-trifluoro-1-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)butan-1-one; BDM41420

CAS Number: 1616242-21-7
Empirical Formula (Hill Notation): C17H19F3N2O2
Molecular Weight: 340.34
Linear Formula: C17H19F3N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2005-5MG 5 mg
 $98.40
1/EA		 Add To Favorites
45-SML2005-25MG 25 mg
 $316.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: Activates an alternative bioactivation pathway of the tuberculosis antibiotic pro-drug ethionamide, reversing resistance.
Biochem/physiol Actions: SMARt-420 (Small Molecule Aborting Resistance) activates an alternative bioactivation pathway of the tuberculosis antibiotic pro-drug ethionamide. Ethionamide bioactivation is normally catalyzed by monooxygenase EthA, but mutations in the enzyme have allowed many strains to become resistant. SMARt-420 activates a previously unknown pathway, reversing ethionamide-acquired resistance and clearing ethionamide-resistant infection in mice in addition to increasing the sensitivity of bacteria to ethionamide.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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