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Cinacalcet hydrochloride

SIGMA/SML2012 - ≥98% (HPLC)

Synonym: AMG 073 hydrochloride; KRN 1493 hydrochloride; N-[1-(R)-(-)-(1-naphthyl)ethyl]-3-[3(trifluoromethyl)phenyl]-1-aminopropane hydrochloride; NPS 1493 hydrochloride

CAS Number: 364782-34-3
Empirical Formula (Hill Notation): C22H22F3N·HCl
Molecular Weight: 393.87
Linear Formula: C22H22F3N·HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2012-10MG 10 mg
 $86.00
1/EA		 Add To Favorites
45-SML2012-50MG 50 mg
 $349.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1
InChI key QANQWUQOEJZMLL-PKLMIRHRSA-N
optical activity [α]/D -24 to -32°, c = 0.5 in methanol
SMILES string FC(F)(F)c1cc(ccc1)CCCN[C@H](C)c2c3c(ccc2)cccc3.Cl
solubility DMSO: 2 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Application: Cinacalcet hydrochloride has been used:
• to stimulate calcium-sensing receptor (CaSR) in thick ascending limb (TAL) of the male Sprague-Dawley rats to study the effect of altered claudins levels on calciuria and magnesiuria in metabolic acidosis
• as a calcimimetic positive allosteric modulator (PAM) of CaSR to determine the structural rearrangements of human CaSR upon activation
• as a calcium-sensing receptor (CaSR) agonist to study the effect of CaSR on tumor cell proliferation in lung adenocarcinoma (LUAD) cell line
Biochem/physiol Actions: Calcimimetic; Calcium Sensing Receptor (CaSR) positive allosteric modulator
Biochem/physiol Actions: Cinacalcet is a positive allosteric modulator of the Calcium Sensing Receptor (CaSR) that acts as a calcimimetic. It increases the sensitivity of the calcium-sensing receptor to extracellular calcium resulting in a decrease in serum calcium levels.
Biochem/physiol Actions: Studies show that oral administration of cinacalcet hydrochloride aids in treating secondary hyperparathyroidism in patients with chronic kidney disease on dialysis. It may also be a potential therapeutic to treat hypercalcemia in patients with parathyroid carcinoma.
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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