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Atrasentan hydrochloride

SIGMA/SML2020 - ≥98% (HPLC)

Synonym: (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic acid hydrochloride; 2R-(4-Methoxyphenyl)-4S-(1,3-benzodioxol-5-yl)-1-(N, N-di(n-butyl)aminocarbonyl-methyl)-pyrrolidine-3R-carboxylic acid hydrochloride; A-147627 hydrochloride; ABT-627 hydrochloride

CAS Number: 195733-43-8
Empirical Formula (Hill Notation): C29H38N2O6 · HCl
Molecular Weight: 547.08
MDL Number: MFCD13194884
Linear Formula: C29H38N2O6 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2020-5MG 5 mg
 $145.00
1/EA		 Add To Favorites
45-SML2020-25MG 25 mg
 $584.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML2020-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C29H38N2O6.ClH/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20;/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34);1H/t23-,27-,28+;/m1./s1
InChI key IJFUJIFSUKPWCZ-SQMFDTLJSA-N
SMILES string [H]Cl.CCCCN(CCCC)C(CN1C[C@H](C2=CC=C(OCO3)C3=C2)[C@@H](C(O)=O)[C@@H]1C4=CC=C(OC)C=C4)=O
solubility DMSO: 2 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: Atrasentan is a selective endothelin ETA receptor antagonist with an IC50 of 0.2 nM for ETA compared to 190 nM for ETB receptors. It blocks blocks endothelin induced cell proliferation, and has been investigated as a possible treatment for prostate cancer, and more recently for therapy for diabetic kidney disease.
Biochem/physiol Actions: Selective endothelin ETA receptor antagonist
General description: Atrasentan has also been used to treat cardiovascular disease.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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