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AGN 193109

SIGMA/SML2034 - ≥98% (HPLC)

Synonym: 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]-benzoic acid; AGN193109; CD 3106

CAS Number: 171746-21-7
Empirical Formula (Hill Notation): C28H24O2
Molecular Weight: 392.49
MDL Number: MFCD00943817
Linear Formula: C28H24O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2034-5MG 5 mg
 $145.00
1/EA		 Add To Favorites
45-SML2034-25MG 25 mg
 $584.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
InChI key NCEQLLNVRRTCKJ-UHFFFAOYSA-N
SMILES string O=C(O)C1=CC=C(C#CC2=CC=C3C(C)(C)CC=C(C4=CC=C(C)C=C4)C3=C2)C=C1
solubility DMSO: 2 mg/mL, clear (warmed)
storage temp. −20°C
Biochem/physiol Actions: AGN 193109 is an orally active retinoic acid receptor (RAR) antagonist that targets all three RAR subtypes with higher affinity (RARα/β/γ Kd = 2 nM) than all-trans retinoic acid/ATRA (RARα/β/γ Kd = 9/12/19 nM). AGN 193109 potently antagonizes against ATRA-induced transcription in RARα, RARβ, and RARγ transfected CV-1 cells (by 85%, 62%, and 100%, respectively, by equal molar AGN 193109 against ATRA). AGN 193109 is also widely employeed to block RAR-mediated physiological and pathalogical processes in mice and rats in vivo via oral (1-10 mg/kg) or topical (0.3-36 μmol/kg) administration.
Biochem/physiol Actions: High-affinity orally active pan-retinoic acid receptor (RAR) antagonist with in vitro and in vivo efficacy.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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