AGN 193109
SIGMA/SML2034 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 171746-21-7
Empirical Formula (Hill Notation): C28H24O2
Molecular Weight: 392.49
MDL Number: MFCD00943817
Linear Formula: C28H24O2
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML2034-5MG.
This image depicts SML2034-5MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C28H24O2/c1-19-4-11-22 |
| InChI key | NCEQLLNVRRTCKJ-UHFFFAOYSA |
| SMILES string | O=C(O)C1=CC=C(C#CC2=CC=C3 |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage temp. | −20°C |
| Biochem/physiol Actions: | AGN 193109 is an orally active retinoic acid receptor (RAR) antagonist that targets all three RAR subtypes with higher affinity (RARα/β/γ Kd = 2 nM) than all-trans retinoic acid/ATRA (RARα/β/γ Kd = 9/12/19 nM). AGN 193109 potently antagonizes against ATRA-induced transcription in RARα, RARβ, and RARγ transfected CV-1 cells (by 85%, 62%, and 100%, respectively, by equal molar AGN 193109 against ATRA). AGN 193109 is also widely employeed to block RAR-mediated physiological and pathalogical processes in mice and rats in vivo via oral (1-10 mg/kg) or topical (0.3-36 μmol/kg) administration. |
| Biochem/physiol Actions: | High-affinity orally active pan-retinoic acid receptor (RAR) antagonist with in vitro and in vivo efficacy. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |