DMAT
SIGMA/SML2044 - ≥98% (HPLC)
Synonym: CK2 Inhibitor II; 2-
CAS Number: 749234-11-5
Empirical Formula (Hill Notation): C9H7Br4N3
Molecular Weight: 476.79
MDL Number: MFCD08705322
Linear Formula: C9H7Br4N3
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C9H7Br4N3/c1-16(2)9-14 |
| InChI key | SLPJGDQJLTYWCI-UHFFFAOYSA |
| shipped in | wet ice |
| SMILES string | CN(C)c1nc2c(Br)c(Br)c(Br) |
| storage temp. | −20°C |
| Application: | DMAT has been used as a casein kinase 2 (CK2) inhibitor: • to study its effects on parasite multiplication in a [3H]-hypoxanthine incorporation assay • to study its effects on the intracellular response in prostate cancer cells • to study its effects on cell division cycle 25C (cdc25C) phosphatase levels in prostate cancer cells |
| Biochem/physiol Actions: | Casein kinase II inhibitor II (Ck2 Inhibitor II) is a ATP competitive inhibitor of casein kinase II. |
| Biochem/physiol Actions: | Casein kinase II inhibitor II (Ck2 Inhibitor II) is a high affinity ATP-competitive inhibitor of casein kinase II. Ck2 Inhibitor II inhibits CK2 in rat liver with 1,300-fold greater selectivity for CK2 than for CK1 (IC50 = 140 nM and >200 μM respectively). Ki = 40 nM; In Jurkat human T-cell leukemia cells, Ck2 Inhibitor II does not display side effects on mitochondria polarization at concentrations up to 10 μM; Ck2 Inhibitor II is useful for in vivo studies due to cell permeability and high efficacy in cultured cells and has implications in research and treatment of neoplasia and infective diseases, in which CK2 plays a role and is highly active constitutively. |
| Biochem/physiol Actions: | DMAT is an ATP-competitive (Ki = 40 nM) casein kinase 2 (CK2) inhibitor (IC50 = 140 nM; rat liver CK2, [ATP] = 20 nM) with greatly improved potency and selectivity than its structure analog TBB. With the exception of DYRK1a (IC50 = 120 nM), DMAT is reported to exhibit no CK1 inhibitiory potency up to 200 μM (50% inhibition by 29 μM TBB) and little or no activity against a panel of 32 other protein kinases, nor PI3K α and γ. When tested in Jurkat cultures, DMAT is shown to be a superior apoptosis inducer than TBB (DC50 = 2.7 μM/DMAT vs. 17 μM/TBB). |
| Disclaimer: | Air sensitive |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |