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R-IMPP hydrochloride

SIGMA/SML2045 - ≥98% (HPLC)

Synonym: (R)-N-(isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-(piperidin-3-yl)propanamide hydrochloride

CAS Number: 2173005-10-0
Empirical Formula (Hill Notation): C24H27N3O2 · xHCl
Molecular Weight: 389.49 (free base basis)
Linear Formula: C24H27N3O2 · xHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2045-5MG 5 mg
 $98.40
1/EA		 Add To Favorites
45-SML2045-25MG 25 mg
 $397.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C24H27N3O2.ClH/c1-29-21-11-8-18(9-12-21)10-13-23(28)27(20-6-4-15-25-17-20)24-22-7-3-2-5-19(22)14-16-26-24;/h2-3,5,7-9,11-12,14,16,20,25H,4,6,10,13,15,17H2,1H3;1H/t20-;/m1./s1
InChI key OSIRDWNTKGVIOE-VEIFNGETSA-N
SMILES string O=C(CCC1=CC=C(OC)C=C1)N([C@H]2CNCCC2)C3=C(C=CC=C4)C4=CC=N3.[H]Cl
solubility DMSO: 2 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: Potent and selective inhibitor of PCSK9 secretion
Biochem/physiol Actions: R-IMPP is a potent and selective inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) secretion that stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. R-IMPP binds selectively to human ribosomes and causes transcript-dependent inhibition of PCSK9 translation.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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