BPAM344

SIGMA/SML2047 - ≥98% (HPLC)

Synonym: BPAM344; 4-Cyclopropyl-3,4-dihydro-7-fluoro-2H-1,2,4-benzothiadiazine 1,1-dioxide

CAS Number: 1204572-55-3
Empirical Formula (Hill Notation): C₁₀H₁₁FN₂O₂S
Molecular Weight: 242.27
Linear Formula: C₁₀H₁₁FN₂O₂S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML2047-5MG	5 mg	$129.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C10H11FN2O2S/c11-7-1-4-9-10(5-7)16(14,15)12-6-13(9)8-2-3-8/h1,4-5,8,12H,2-3,6H2
InChI key	FLTMTBPCYAZIKM-UHFFFAOYSA-N
SMILES string	O=S1(C2=CC(F)=CC=C2N(C3CC3)CN1)=O
storage temp.	2-8°C

Biochem/physiol Actions:	BPAM344 is a potent positive allosteric modulator (PAM) on the three KAR subunits GluK1b, GluK2a, and GluK3a. BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold, and noticeably decreases desensitization kinetics (from 5.5 to 775 ms).
Biochem/physiol Actions:	Potent positive allosteric modulator (PAM) on the three KAR subunits GluK1b, GluK2a, and GluK3a

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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