Synonym: 3-[[5-(Ethylthio)-1,3,4-thiadiazol-2-yl]thio]-2-pyrazinecarbonitrile; 3-[[5-(Ethylthio)-1,3,4-thiadiazol-2-yl]thio]pyrazine-2-carbonitrile; Compound A
CAS Number: 1000269-30-6
Empirical Formula (Hill Notation): C9H7N5S3
Molecular Weight: 281.38
Linear Formula: C9H7N5S3
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to brown |
| form |
powder |
| InChI |
1S/C9H7N5S3/c1-2-15-8-13-14-9(17-8)16-7-6(5-10)11-3-4-12-7/h3-4H,2H2,1H3 |
| InChI key |
UBSFSJMIJHSGDZ-UHFFFAOYSA-N |
| SMILES string |
CCSC1=NN=C(S1)SC2=NC=CN=C2C#N |
| solubility |
DMSO: 2 mg/mL, clear |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
LCAT activator compound A is an activator of Lecithin:cholesterol acyltransferase (LCAT) including some mutant LCATs found in Familial LCAT Deficiency (FLD). LCAT activator compound A forms a covalent hydrophobic adduct with LCAT Cys 31. The chronic treatment with LCAT activator compound A results in a significant increase in HDLc, HDL particle, size, plasma apolipoprotein A-I level, plasma cholesteryl ester to free cholesterol ratio, and a significant reduction in very low-density lipoprotein cholesterol in hamsters. |
| Biochem/physiol Actions: |
Lecithin:cholesterol acyltransferase (LCAT) including some FLD mutant LCATs |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
41106609 |
