ZD0947

SIGMA/SML2055 - ≥98% (HPLC)

Synonym: 3-[(4 S)5-Oxo-2-(trifluoromethyl)-1,4,5,6,7,8-hexahydroquinolin-4-yl] benzonitrile; 3-[(4S)-1,4,5,6,7,8-Hexahydro-5-oxo-2-(trifluoromethyl)-4-quinolinyl]-benzonitrile

CAS Number: 172649-40-0
Empirical Formula (Hill Notation): C₁₇H₁₃F₃N₂O
Molecular Weight: 318.29
MDL Number: MFCD00944017
Linear Formula: C₁₇H₁₃F₃N₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML2055-25MG	25 mg	$397.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C17H13F3N2O/c18-17(19,20)15-8-12(11-4-1-3-10(7-11)9-21)16-13(22-15)5-2-6-14(16)23/h1,3-4,7-8,12,22H,2,5-6H2/t12-/m0/s1
InChI key	RUVMMEREJMHLOS-LBPRGKRZSA-N
optical activity	[α]/D -625 to -575°, c = 0.5 in methanol
SMILES string	O=C1C2=C(NC(C(F)(F)F)=C[C@H]2C3=CC(C#N)=CC=C3)CCC1
solubility	DMSO: 2 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	potent ATP-sensitive K+ channels (KATP channels) opener
Biochem/physiol Actions:	ZD0947 is potent ATP-sensitive K+ channels (KATP channels) opener. ZD0947 is an effective activator of smooth muscle-type KATP channels (SUR2B/Kir6.1 and SUR2B/Kir6.2) but is a partial antagonist of pancreatic-type KATP channels (i.e. SUR1/Kir6.2) and cardiac-type KATP channels (i.e. SUR2A/Kir6.2). ZD0947 potently inhibits carbacho-induced contraction in the strips of human detrusor.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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